Correlation between Pulmonary Hypertension Induced by High Blood Flow and Nuclear Factor-?B
- VernacularTitle:高血流介导的肺动脉高压与核转录因子-?B的相关性
- Author:
xiao-xiao, YU
;
jie, YANG
;
ruo-peng, SUN
- Publication Type:Journal Article
- Keywords:
congenital heart disease;
pulmonary hypertention;
pulmonary vascular remolding;
nuclear factor-?B
- From:Journal of Applied Clinical Pediatrics
2006;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
Congenital heart disease with left-to-right shunt easily lead to pulmonary hypertension.Currently agreed about its mechanism:shear stress induced by high pulmonary blood flow stimulus pulmonary endothelium,to start regulation of genetic transcription,to initiate a series of molecular biology and pathophysiology changes,and finally to lead to pulmonary vascular pathologic remolding.Nuclear factor(NF)-?B is a kind of nuclear factor with multiple biological effect and play an important role in pulmonary vascular remolding.NF-?B signal can be actiacted by high blood flow.Its target gene products,for example,vasoactive mediators,cytokines,make pulmonary vessels difficulty to maintain the normal structure and cause pulmonary vascular contraction and remolding,thus,pulmonary arterial pressure increases.
