Expressions of Connexin32 and Connexin43 in Hippocampus and Effect of Carbenoxolone on Their Expression in Epileptic Immature Rats Induced by Lithium-Pilocarpine
- VernacularTitle:CX32和CX43在癫幼鼠海马区的表达及甘珀酸对其的干预作用
- Author:
tian-ming, JIA
;
hong, DAI
;
juan, CAO
- Publication Type:Journal Article
- Keywords:
epilepsy;
gap junction;
connexin 32;
connexin 43;
carbenoxolone
- From:Journal of Applied Clinical Pediatrics
2004;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the behavior changes and connexin 32(CX32),connexin 43(CX43)expressions in hippocampus and the effect of carbenoxolone on their expression in epileptic immature rats induced by lithium-pilocarpine.Methods Seventy-two SD immature rats of 21 d were randomly divided into control group(n=24),lithium-pilocarpine kindled group(n=24)and carbenoxolone treated group(n=24),each group by 24 h,3 d,7 d and 30 d were subdivided into 4 groups(n=6).Immuno-histochemisty was used to observe the expressions of CX32 and CX43 in hippocampus areas of immature rats,and to observe their behavior changes.Results The scores of the severe elileptiform seizures(Racine Ⅳ/Ⅴlevel)in lithium-pilocarpine group were significantly higher than those in carbenoxolone treated group;The latency in carbenoxolone treated group was prolonged significantly(P
