Expressions and Significance of p21 Protein and K-ras Protein in Congenital Biliary Dilatation
- VernacularTitle:p21蛋白与K-ras蛋白在先天性胆管扩张症中的表达及其意义
- Author:
liang, ZHOU
;
ming-fa, WEI
- Publication Type:Journal Article
- Keywords:
biliary dilation;
choledochal cyst;
bile duct disease;
p21 protein;
K-ras protein;
immunohistochemistry
- From:Journal of Applied Clinical Pediatrics
2004;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions and significance of p21 protein and K-ras protein in congenital biliary dilatation(CBD),and their relationship.Methods Surgical specimens of CBD were obtained during operation on 36 children from Jan.2000 to Sep.2007.Nine normal bile ducts specimens from miscarried fetus and children's corpse.The specimens were fixed in 40 g?L-1 formalin and embeded by paraffin,slice-fixed.SP immunohistochemical method was used to detect the expressions of p21 protein and K-ras protein.Results The positive rate of K-ras protein was 13.8% in CBD,which was significantly higher than that in normal bile duct tissues.The positive rate of p21 protein was 55.6% in CBD,and 100% in normal bile duct tissues.p21 protein positive expression rate in CBD was significantly lower than that in normal bile duct tissues(P
