Role and Clinical Significance of Myeloid Differentiation Protein-2 in Endotoxin Signal Transduction
- VernacularTitle:髓样分化蛋白-2在转导内毒素信号中的作用及临床意义
- Author:
xi-hua, YUAN
;
chang-hui, CHEN
- Publication Type:Journal Article
- Keywords:
myeloid differentiation protein-2;
lipopolysaccharide;
toll-like receptor 4;
signal transduction;
infection;
infant,newborn
- From:Journal of Applied Clinical Pediatrics
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Myeloid differentiation protein-2(MD-2)can separately and simultaneously bind lipopolysaccharide(LPS)and toll-like receptor 4(TLR4)has been shown to play critical roles in mediated recognition responses to LPS by TLR4 and signal transduction induced by LPS.MD-2 can be bound by LPS,not TLR4.The cells have no responsiveness or weak responsiveness to LPS without MD-2.MD-2 can be secreted into blood plasma,formed soluble MD-2 and remotely regulated cells that contained TLR4 without MD-2.MD-2 has been shown to play important roles in endotoxin signal transduction.MD-2 is a small molecular,short nucleic acid fragment,easily regulated should become a new potential anti-inflammatory target.
