Changes of Hydrogen Sulfide and Heme Oxygenase-1 of Children with Congenital Heart Disease Combined with Pulmonary Hypertension and Those Significances
- VernacularTitle:先天性心脏病合并肺动脉高压患儿手术前后血硫化氢及血红蛋白氧合酶-1变化的意义
- Author:
xiao-rong, ZHANG
;
xiao-ping, RONG
- Publication Type:Journal Article
- Keywords:
pulmonary hypertension;
congenital heart disease;
hydrogen sulfide;
heme oxygenase-1
- From:Journal of Applied Clinical Pediatrics
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical significance of hydrogen sulfide(H2S)and heme oxygenase-1(HO-1)on pulmonary hypertension(PH),by detecting their levels of patients with congenital heart disease(CHD).Methods Forty-eight patients with CHD who had left-to-right shunt were selected randomly from cardiac surgery in the Fourth Hospital of Hebei Medical University.Forty-eight patients were performed successfully on radical operation under complex intravenous anesthesia,and they were divided 3 groups according to pulmonary artery systolic pressure(PASP)detected by doppler echocardiography before operation:no PH group(PASP0.05).Conclusions H2S plays an important role in the formation of PH and restructure.There is no correlation between PASP and HO-1 activities in serum,but HO-1 may be play an indirect action in the formation of PH and restructure.Measuring the levels of H2S may be a reliable method to follow the change of pulmonary pressure and worsening of PH.
