Influence of Dexamethasone and Fructose-1,6-Diphosphate on Myocardial Enzymes and Ultrastructure of Myocardial Cells in Rats with Endotoxemia
- VernacularTitle:地塞米松、1,6-二磷酸果糖对内毒素血症大鼠心肌酶及心肌超微结构的影响
- Author:
guang, TANG
;
dan, WEI
- Publication Type:Journal Article
- Keywords:
endotoxemia;
myocardial cell;
dexamethasone;
fructose-1,6-diphosphate;
ultrastructure
- From:Journal of Applied Clinical Pediatrics
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of dexamethasone(DXM)and fructose-1,6-diphosphate(FDP)on cardial troponin I(cTnI)and MB isoenzyme of creatine kinase(CK-MB),and ultrastructure of myocardial cells in rats with endotoxemia.Methods Eighty SD rats were randomly divided into 4 groups:sodium chloride group(NS group,n=8),9 g?L-1 NS 1 mL,ip;lipopolysaccharide group(LPS group,n=24),administered with endotoxin(5 mg?kg-1,ip);DXM group(n=24):received DXM(5 mg?kg-1,ip)after injection of LPS 1 h;FDP(n=24)group,received FDP(1 g?kg-1,ip)after injection LPS 1 h.Then,they were sacrificed at 6 h,12 h,24 h and 72 h after injection.CK-MB and cTnI in blood were detected with chemiluminescent techniques,and myocardial pathological damage was observed under the light and transmission electron microscope.Results Compared with control group,in LPS group,the serum cTnI and CK-MB were increased significantly from 6 h to 24 h with time going by(P
