Advances in Bosentan Treatment for Pediatric Pulmonary Arterial Hypertension
- VernacularTitle:波生坦治疗儿童肺动脉高压的研究进展
- Author:
tao, WANG
;
wen-wen, CAI
;
han-min, LIU
- Publication Type:Journal Article
- Keywords:
bosentan;
pulmonary arterial hypertension;
child
- From:Journal of Applied Clinical Pediatrics
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Bosentan is a non-selective endothelin receptor antagonist,which plays an important role in the treatment of children with pulmonary arterial hypertension.Bosentan has shown to improve exercise capacity,hemodynamics and reduce pulmonary vascular resistance in pediatric patients.The main adverse effect is less severely comparing with the adult.The combination of bosentan with other drugs can improve the life quality furtherly.Further study of large-scale trials needs focus on the long-effects of bosentan,the ideal period of therapy and the effects of combination therapy in children.
