Relationship of Renal Injury and Expression of Macrophage Migration Inhibitory Factor in Renal Tissue of Henoch-Schonlein Purpura Nephritis in Children
- VernacularTitle:紫癜性肾炎患儿肾组织巨噬细胞移动抑制因子表达与肾损伤的关系
- Author:
rui, FU
;
dou-xing, HAN
;
yin, ZOU
;
hong, LIU
;
bao-jin, HU
;
qiang, XIAO
- Publication Type:Journal Article
- Keywords:
macrophage migration inhibitory factor;
Henoch-Schonlein purpura nephritis;
child
- From:Journal of Applied Clinical Pediatrics
2006;0(23):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of macrophage migration inhibitory factor(MIF) in renal tissue of children with Henoch-Schonlein purpura nephritis(HSPN),and its correlation with clinical indexes and pathological changes,and to explore its effect on the pathogenesis of HSPN.Methods According to the clinical manifestation,60 children with HPSN were divided into only purpura group,mixed group and HSPN group.MIF concentration of Henoch-Schonlein purpura(HSP) groups and healthy control group were detected with enzyme linked immunosorbent assay(ELISA).MIF protein expression and the marker of human macrophage(CD68) in renal tissues of HSPN and normal control group were detected with immunohistochemistry method.The total urine protein for 24 hours and urinary N-acetyl-beta-D-glucosaminidase (NAG) level were detected with laboratory routine method.Results MIF concentration in mixed group and HSPN group were significantly higher than that in only purpura group and healthy control group(Pa
