Significance of Changes of Plasma Levels of Tissue Factor Pathway Inhibitor in Children with Henoch-Schonlein Purpura Treated by Heparin
- VernacularTitle:肝素治疗过敏性紫癜患儿血浆组织因子途径抑制物水平变化的意义
- Author:
shao-min, REN
;
shu-ling, ZHAO
;
chun-xia, ZHANG
;
wei-cai, LI
- Publication Type:Journal Article
- Keywords:
Henoch-Schenlein purpura;
tissue factor pathway inhibitor;
heparin;
child
- From:Journal of Applied Clinical Pediatrics
2006;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the plasma levels of tissue factor pathway inhibitor(TFPI)in children with Henoch-Schonlein purpura(HSP)and the changes of it after therapy with heparin.Methods Forty-six HSP children were enrolled in HSP group according to the criterion,and 23 normal healthy children as controls.The plasma levels of TFPI were measured by enzyme linked immunosorbent assay in both groups.Forty-six HSP children were divided into 2 groups randomly:heparin therapy group(n=23)and conventional therapy group(n=23).The plasma levels of TFPI were measured before therapy,on the 7th day and the 14th day after therapy,respectively.Results 1.The plasma levels of TFPI in HSP group [(59.337?21.750)?g/L] significantly decreased than those of control group [(88.761?12.214)?g/L](t=7.185 P
