Relationship of Janus Kinase-Signal Transducers and Activator of Transcription Signal Transduction and Neurogenesis in Neonatal Rats with Periventricular Leukomalacia
- VernacularTitle:脑室周围白质软化新生大鼠酪氨酸蛋白激酶-信号转导和转录激活因子信号转导与神经再生的关系
- Author:
xi-ge, WANG
;
ying, XIONG
- Publication Type:Journal Article
- Keywords:
signal transducers and activator of transcription;
neurogenesis;
hypoxia-ischemia;
periventricular leukomalacia;
neonatal rats
- From:Journal of Applied Clinical Pediatrics
2006;0(20):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the relationship of the Janus kinase-signal transducers and activator of transcription pathway and neurogenesis in the lateral ventricle subventricular zone(SVZ) and choroid plexus of neonatal rats with periventricular leukomalacia(PVL).Methods PVL models were established by right common carotid artery ligation followed by 4 h 60 mL/L oxygen exposure in 2-day-rat;the neonatal rats performed a sham operation,without hypoxia-ischemia were used as control group.The rats were sacrificed at 0 h,3 h,6 h,12 h,1 d,3 d and 7 d after hypoxic-ischemic(HI),and brain tissues were collected,immunohistochemistry was used to detect the expression of P-STAT3 and Nestin in the subventricular zone and choroid plexus.Results Very low expressions of P-STAT3 and Nestin were observed in lateral ventricle SVZ and choroid plexus in control group.The expression levels of P-STAT3 and Nestin increased significantly after HI,peaked at 1 d and 3 d separately,and remained at a higher level at 7 d after HI,demonstrating significant differences at each time point compared with those in control group(Pa
