Genetics Research of Multidrug Resistance Protein 3,Farnesoid X Receptor Gene in Intrahepatic Cholestasis
- VernacularTitle:MDR3、FXR基因在肝内胆汁淤积的遗传学研究进展
- Author:
xiu-qi, CHEN
;
lin-lin, WANG
- Publication Type:Journal Article
- Keywords:
intrahepatic cholestasis;
multidrug resistance protein 3;
farnesoid X receptor gene
- From:Journal of Applied Clinical Pediatrics
2006;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
The etiology and pathogenesis of intrahepatic cholestasis are complex,and those are not still very clear in current.Studies suggest that genetic factors play an important role in the pathogenesis of the disease.Some familial cholestasis have been confirmed by gene mutation causing.Bile secretion process regulated by a number of bile relation gene at the molecular level.Farnesoid X receptor (FXR) gene is related to intrahepatic bile secretion process.Bile secretion is indirect control by FXR which formats a complex network,becoming more attention to researcher in recent years.
