Influence of Heme Oxygenase-1 Inhibitor Protoporphyrin Ⅸ Zinc on Hyperoxic Lung Injury in Preterm Rats
- VernacularTitle:血红蛋白氧合酶-1抑制剂锌原卟啉对高体积分数氧肺损伤早产大鼠的影响
- Author:
yu-feng, QUAN
;
ming-ci, ZHENG
;
hua, ZHANG
;
pei-lin, ZHANG
;
hong, ZHANG
- Publication Type:Journal Article
- Keywords:
heme oxygenase;
hyperoxia;
lung;
protoporphyrin Ⅸ zinc;
preterm rat
- From:Journal of Applied Clinical Pediatrics
2006;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of protoporphyrin Ⅸ zinc(Znpp) on hyperoxic lung injury in preterm rats.Methods Three-day-old preterm SD rats were randomly assigned to room air control group(group Ⅰ)hyperoxia control group(oxygen≥900 mL/L)(group Ⅱ),room air plus Znpp group(group Ⅲ),hyperoxia plus Znpp group(group Ⅳ).Group Ⅲ and group Ⅳ were injected intraperitoneally with ZnPP 45 ?mol/kg each day.After the third day and the 7th day of exposure,the activity of heme oxygenase-1(HO-1) and the percent of carboxyhemoglobin(HbCO) in the lungs,the lung wet weight /dry weight ratio(W/D),tumor necrosis factor-?(TNF-?),total protein and malondialdehyde(MDA) in bronchoalveolar lavage fluid were determined and lung histophathological changes were examined in all groups.Results On the third day,compared with group Ⅰ the activity of HO-1 and the percent of HbCO in the lungs,W/D,TNF-?,total protein and MDA,all greatly rised in group Ⅱ(Pa
