Effect of Anti-Epileptic Drugs on Thyroid Structure and Endocrine Function in Rats
- VernacularTitle:抗癫药对大鼠甲状腺结构及分泌激素的影响
- Author:
yan, SUN
;
yu-xing, GAO
- Publication Type:Journal Article
- Keywords:
valproic acid;
oxcarbazepine;
levetiracetam;
thyroid hormone;
thyroid structure;
rat
- From:Journal of Applied Clinical Pediatrics
2006;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).Thyroid follicular volume of VPA group slightly reduced;thyroid follicular volume of OXC group increased while epithelial cells thinning;thyroid structure of LEV group had no alterations;thyroid follicular volume of OXC plus LEV group and VPA plus LEV group had no consistent alterations.Conclusions Long-term application of VPA and OXC may arouse alterations of thyroid structure and hormone secretion.LEV has no effection on thyroid function,with VPA and OXC combined usage can reduce their effection on thyroid gland.Thyroid hormone level should be monitored when using anti-epileptic drugs(ADES) long-term in clinical work.
