Study Progress on Relationship of Transforming Growth Factor-?_1 and Airway Remodelig in Asthma
- VernacularTitle:转化生长因子-?_1与支气管哮喘患者呼吸道重塑的关系研究进展
- Author:
yu-mei, LI
;
cai-xia, AN
;
ying, ZHAO
;
bin, LI
;
ming-xia, GAO
- Publication Type:Journal Article
- Keywords:
asthma;
transforming growth factor-?1;
airway remodeling;
advance
- From:Journal of Applied Clinical Pediatrics
2006;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
Transforming growth factor-?1 (TGF-?1) was reported to play an important role in the pathogenesis of asthma in many stu-dies.It can stimulate the growth of fibroblast and give rise to fibrosis of lung tissues.Many scholars think that TGF-?1 is closely related to airway remodeling.It is a breakthrough to aim at TGF-?1 to find a way to intervene remodeling in asthma.Glucocorticoid (Dexamethasone and Budesonide) can have an impact in some extent to airway remodeling.In addition,interferon-? and some traditional chinese medicine such as ligustrazine,tripterygium wilfordii and ginkgo maybe effective,they all may ameliorate the progression of airway remodeling following redu-cing partial airway TGF-?1 expression.
