Serum Concentration Monitoring and High-Dose Methotrexate Chemotherapy for Osteosarcoma in Children
- VernacularTitle:血清药物浓度监测下大剂量甲氨蝶呤治疗儿童恶性骨肿瘤
- Author:
hong, TANG
;
shu-xu, DU
;
li-ming, SUN
- Publication Type:Journal Article
- Keywords:
osteosarcoma;
methotrexate;
serum concentration;
child
- From:Journal of Applied Clinical Pediatrics
2006;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
1.0 ?mol/L),the toxicity and side effects of MTX increased significantly.The most common drug side effects were gastrointestinal symptoms and leucopenia.The oral mucosal lesions became worse in 12 g/m2 group.Conclusion The monitoring of HD-MTX plasma concentration provides an objective clinical basis for the individualized chemotherapy.
