Study Progress on Relationship between Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor Receptor and Hematologic Malignancy
- VernacularTitle:血管内皮生长因子及其受体与血液系统恶性肿瘤的关系研究进展
- Author:
xiao-dan, CHANG
;
ming-zhen, CHEN
- Publication Type:Journal Article
- Keywords:
vascular endothelial growth factor;
receptor;
hematologic malignancy;
ribonucleic acid interference
- From:Journal of Applied Clinical Pediatrics
2006;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
Vascular endothelial growth factor(VEGF) is one of the best characterized angiogenic regulators which has many effects in promoting endotheliocyte proliferation and differentiation,increasing the microvascular permeability,inducing the angiogenesis,triggering the growth,survival and migration of tumor cells by combining its specificity receptor (VEGFR).Dysregulation of VEGF expression and signaling pathways therefore plays a pivotal role in the pathogenesis and clinical features of hematologic malignancies,direct and indirect targeting of VEGF and its receptors therefore may provide a potent novel therapeutic approach to overcome bone marrow angiogenesis and multidrug resis-tance thereby improve patient outcome.Recent years,a novel VEGF blockade system using RNA interference attracts more and more people's attention.The small interfering RNA (siRNA) targeting VEGF/VEGFR can completely inhibits the expression of VEGF and induce the silence of corresponding genes.
