Diagnostic Value of Urine Cystatin C for Renal Function Impairment in Neonates with Hypoxic-Ischemic Encephalopathy
- VernacularTitle:尿胱抑素C对缺氧缺血性脑病新生儿肾功能的诊断价值
- Author:
cai-yun, YANG
;
ying, SHEN
;
ying, LIN
;
yan, ZHONG
;
hui-xin, WANG
;
xue-fang, YANG
;
ying, LIU
- Publication Type:Journal Article
- Keywords:
Cystatin C;
hypoxic-ischemic encephalopathy;
renal function;
infant,newborn
- From:Journal of Applied Clinical Pediatrics
2006;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value of urine Cystatin C(Cys C) for renal function impairment in neonates with hypoxic-ischemic encephalopathy(HIE).Methods The urine Cys C concentration was measured by enzyme linked immunosorbent assay(ELISA) in 47 cases of HIE newborns(25 cases were mild HIE and 22 cases were moderate-severe HIE) within 3 days after their birth.Twenty-three cases without perinatal asphyxia or other factors which could result in renal function impairment were selected as control group.Urine Cys C with urine retinal-bindingprotein(RBP),?2-microglobulin(?2-MG) and fractional sodium excretion(FENa%) were analyzed by kolmogorov-smirno in each group.Results Compared with control group,the concentration of urine Cys C,RBP and the levels of FENa% in HIE newborns were significantly elevated.The levels of urine Cys C in moderate-severe HIE newborns were significantly higher than those in mild HIE newborns(Pa
