Expressions of Transforming Growth Factor-?1 and Connective Tissue Growth Factor in Viral Myocarditis and Intervention Effect of Valsarta on Them
- VernacularTitle:转化生长因子-?_1及结缔组织生长因子在病毒性心肌炎小鼠中的表达及缬沙坦的干预作用
- Author:
heng, LI
;
xiao-qin, ZHOU
;
xia, GAO
- Publication Type:Journal Article
- Keywords:
connective tissue growth factor;
transforming growth factor-?1;
valsarta;
viral myocarditis;
mouse
- From:Journal of Applied Clinical Pediatrics
2006;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expressions of transforming growth factor(TGF)-?1 and connective tissue growth factor(CTGF) in viral myocarditis(VM) and the intervention effect of valsarta on them.Methods Fifty-four male Balb/c mice were randomly divided into 3 groups:control group,treatment group and model group.Model group and treatment group established VM model by intraperitoned injecting 0.1 ml CVB3.They were killed on days 7,14 and 28,respectively.Histological cross sections of heart were stained with hematoxylin-eosin and myocardial histopathplogic scores were counted under optical microscope.The expressions of typeⅠand Ⅲ myocardial collagen,TGF-?1 and CTGF were examined by immunohistochemical method and analyzed by using SPSS 11.5 software.Results Compared with control group,histopathplogic scores,the expressions of type Ⅰand Ⅲ myocardial collagen,TGF-?1 and CTGF increased markedly in model group (Pa
