Association of Serum Adiponectin and Metabolic Syndrome in Children with Obesity and Nonalcoholic Fatty Liver Disease
- VernacularTitle:肥胖及伴非酒精性脂肪肝病儿童血清脂联素与代谢综合征的相关性
- Author:
xiao-yuan, ZHAO
;
xiu-yuan, DING
;
ling-hui, MENG
;
mei-xian, ZHANG
;
jie, MI
- Publication Type:Journal Article
- Keywords:
obesity;
nonalcoholic fatty liver disease;
adiponectin;
child
- From:Journal of Applied Clinical Pediatrics
2004;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum adiponectin and metabolic syndrome(MS) in children and adolescents with obesity and nonalcoholic fatty liver disease(NAFLD).Methods Four elementary schools and 4 middle schools were selected from Haidian district in Beijing with representative cluster sampling.Two hundred and eighty obese children(obese group),65 obese children with NAFLD(NAFLD group) and 264 normal weight children(healthy control group) aged 7 to 18 years were recruited from the 8 schools with uncompletely randomized sampling.Data including questionnaire,anthropometric measurements,B type ultrasonographic examination for liver were collected and fasting blood laboratory assay were determined.Variables including triglyceride(TG),adiponectin,alanine aminotransferase(ALT) and aspartate aminotransferase(AST) were skewed distribution and natural logarithmical transformations were performed.Chi-square test for category and multiple binary Logistic regression analysis were used to statistical analysis.Results Body mass index(BMI) and waist circumference(WC) in obese group and NAFLD group were higher than those in healthy control group.All the chi-square tests for trend among the 3 groups were statistically significant(P
