Changes of the Activity of Nuclear Factor-?B in Neonatal Rat Model of Necrotizing Enterocolitis and Intervention Effect of Intestinal Trefoil Factor on Them
- VernacularTitle:坏死性小肠结肠炎新生大鼠核因子-?B活性变化及肠三叶因子的干预作用
- Author:
hai-xia, ZHANG
;
bing-hong, ZHANG
;
lei, SHI
- Publication Type:Journal Article
- Keywords:
necrotizing enterocolitis;
intestinal trefoil factor;
nuclear factor-?B;
rat,newborn
- From:Journal of Applied Clinical Pediatrics
2004;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of intestinal trefoil factor(ITF) on nuclear factor-?B(NF-?B) in neonatal rats intestinal tissues with necrotizing enterocolitis(NEC),and to discuss whether ITF had protective function in NEC,and its role in the mechanism of NEC.Methods Fifty neonatal rats were randomly divided into 5 groups:group A as control group,group B as control plus ITF 0.2 mg group,group C as NEC group,group D as NEC plus normal saline(NS),group E as NEC plus ITF 0.2 mg.NEC models of neonatal rats were established.On the 4th day,all subjects were put to death.The intestinal tissue located at the boundary of ileum and cecum were obtained to observe histological changes and NF-?B level.Results The density of NF-?B(p65) increased significantly in group C and D compared with those in group A,B and E(Pa
