Correlation between B beta-Fibrinogen Gene Polymorphism,Plasma Fibrinogen Level and Henoch-Schoenlein Purpura in Children
- VernacularTitle:纤维蛋白原基因多态性及血浆纤维蛋白原水平与过敏性紫癜的相关性
- Author:
zhen-hua, WANG
;
li-hong, LI
;
ji-rong, LU
;
lin-fei, DENG
;
xia, YU
- Publication Type:Journal Article
- Keywords:
Henoch-Schoenlein purpura;
fibrinogen;
gene polymorphism;
child
- From:Journal of Applied Clinical Pediatrics
2004;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of B?-fibrinogen gene-455G/A polymorphism and plasma fibrinogen levels with Henoch-Schoenlein purpura(HSP) in children.Methods Sixty-seven children(including 40 boys and 27 girls) with HSP were served as HSP group,age ranging from 5-14 years,with the average age of 9 years.Seventy healthy controls(including 37 boys and 33 girls) were served as healthy controls.Age ranging from 5-13 years,with the average age of 9 years.The B?-fibrinogen gene-455G/A polymorphism was detected in all subjects by polymerase chain reaction-restrictive fragment length polymorphism technique with restrictive enzyme HaeⅢ.Results There were a greater proportion of individuals with the AA,GA,GG genotype in the HSP group comparied with those of the healthy controls(?2=29.5 P0.05].Conclusions The B?-fibrinogen gene-455G/A mutation is correlated with HSP in children,A allele is susceptibility gene of HSP in children.The plasma fibrinogen level is related to HSP in children.
