Study Progress on Pathogenesis of Idiopathic Thrombocytopenic Purpura
- VernacularTitle:特发性血小板减少性紫癜发病机制研究进展
- Author:
jun-hong, ZHANG
;
you-hua, XU
- Publication Type:Journal Article
- Keywords:
idiopathic thrombocytopenic purpura;
T lymphocyte;
cell-mediated immune;
pathogenesis
- From:Journal of Applied Clinical Pediatrics
2004;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Idiopathic thrombocytopenic purpura(ITP) as an autoimmune disease,is the most common clinical hemorrhagic disease.But,its pathogenesis is not completely clear yet.Low platelet count can easily repeate in chronic ITP patients,there are poor efficacy in refractory ITP patients,too.In recent years,a series of important progress on the pathogenesis of ITP had been made.In the humoral mechanism,there were significant progress on the emergence of autoantibodies;the theory on anomaly of the megakaryocyte quantity and quality caused by autoantibody were put forward.In the cellular mechanisms,the theory on reduction in the number of Tr cells,Co-stimulative signal and platelets directly dissolved by cytotoxicity T cells were put forward also.This review will be made to sum up the study progress on the pathogenesis of ITP.
