The Effect of Cyclooxygenase-2 Expression on Tumor Volume Response in Patients Treated with Radiotherapy for Uterine Cervical Cancer.
10.3346/jkms.2009.24.6.1170
- Author:
Min Kyu KANG
1
;
Won PARK
;
Yoon La CHOI
;
Eun Yoon CHO
;
Geunghwan AHN
;
HeeRim NAM
;
Seung Jae HUH
;
Yong Chan AHN
;
Do Hoon LIM
;
Dong Ryul OH
;
Duk Soo BAE
;
Byoung Gie KIM
Author Information
1. Department of Radiation Oncology, Yeungnam University College of Medicine, Daegu, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Uterine Cervical Neoplasms;
Cyclooxygenase 2;
Radiotherapy;
Tumor Burden;
Tumor Response
- MeSH:
*Carcinoma, Squamous Cell/enzymology/pathology/radiotherapy;
Cyclooxygenase 2/*metabolism;
Female;
Humans;
Middle Aged;
Multivariate Analysis;
Neoplasm Staging;
*Uterine Cervical Neoplasms/enzymology/pathology/radiotherapy
- From:Journal of Korean Medical Science
2009;24(6):1170-1176
- CountryRepublic of Korea
- Language:English
-
Abstract:
We investigated the correlation between Cyclooxygenase-2 (COX-2) expression and the tumor response in patients with cervical cancer that were treated with curative radiotherapy (RT). Fifty-seven patients with squamous cell carcinoma were treated with concurrent radiochemotherapy (CRCT, n=29) or RT alone (n=28). The response of each patient was evaluated by three serial Magnetic Resonance Imaging examinations: before the start of RT, at four weeks after the start of RT (mid-RT) and at four weeks after the completion of RT (post-RT). Forty-three patients had positive COX-2 expression. The COX-2 negative patients achieved a higher rate of complete response (CR) at mid-RT than did the COX-2 positive patients (28.6% vs. 7.0%, P=0.054), but not at post-RT (64.3% vs. 69.8%). The initial tumor volume was a significant predictor of CR at mid-RT (P=0.003) and post-RT (P=0.004). The multivariate analysis showed that the initial tumor volume (at mid-RT and post-RT) and CRCT (at post-RT) were significant predictors of CR; however, the COX-2 expression was not. In conclusion, the COX-2 expression status has no significant correlation with the tumor response. Further studies on the changes in COX-2 expression levels during RT may be helpful for determination of its role in the tumor response to treatment and patient prognosis.
