Human Genne Myo-Inositol Monophosphatase 2 Gene and Clinical Disease
- VernacularTitle:人肌醇单磷酸酶基因2与临床疾病
- Author:
feng, ZHAO
;
da-bin, WANG
;
dong-chi, ZHAO
- Publication Type:Journal Article
- Keywords:
human gene myo-inositol monophosphatase 2;
gene;
associated disease
- From:Journal of Applied Clinical Pediatrics
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Human genne myo-inositol monophosphatase 2(IMPA2) was recently a novel and promising gen that was associated with disease,especially in mental and neuro diseases.Its locus is in chromosome 18p11 2,about 15 kb.It encodes IMPA2 enzyme.IMPA2 enzyme as a mainly and catalytic inositol plays an important role in cell signaling system.The mechanism of action of IMPA2 gene is still unclear.But in basic research on genetic structure and IMPA2 product,the biochemical functions and crystal structure have gradually been recognized;In the clinical application,the association with disease has been detected in manic depression,schizophrenia and febrile seizuers.IMPA2 even has been a susceptible gene to certain diseases.IMPA2 has increasingly been the hotspot in gene research.
