Significance of Renal Evaluation of Vasopressin-Deficient Brattleboro and Wistar Rats by Using Different Concentrated Gadolinium Diethylenetetramine Pentaacetic Acid Dynamic Enhanced Magnetic Resonance Imaging
- VernacularTitle:不同剂量钆喷替酸葡甲胺动态增强磁共振成像评估先天性血管升压素缺乏鼠肾功能的意义
- Author:
jian-jun, WEN
;
li, YANG
;
jian-guo, WEN
;
hong, ZHANG
;
gui-xian, WANG
;
bao-chi, LIU
- Publication Type:Journal Article
- Keywords:
Gadolinium-diethylenetetramine pentaacetic acid;
magnetic resonance imaging;
kidney function;
Brattleboro rat;
Wistar rat;
vasopressin
- From:Journal of Applied Clinical Pediatrics
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the renal functions of vasopressin-deficient Brattleboro(BB) rats by using different concentrated Gadolinium-diethylenetetramine pentaacetic acid(Gd-DTPA) dynamic enhanced magnetic resonance imaging(MRI).MethodsThe study included 14 BB rats(male rats of 3 month-old) and 14 normal male Wistar rats used as control group.Dynamic MRI was performed by using either a low dosage(0.05 mmol/kg) or a high dosage of Gd-DTPA(0.5 mmol/kg).Data of 0-60 min renal cortex,medulla and pelvic were obtained after using contrast medium.MRI of kidneys at different time was analyzed and the mean relative signal intensity(RSI) was measured.Then the RSI curves of different groups were marked.Data of each group were caculated separately by SPSS 11.0 software.ResultsThe findings demonstrated that RSI curves of the vasopressin-deficient kidneys showed different patterns as compared with those of the control group(P
