Expression of Stromal Cell-Derived Factor-1,Chemokine Receptor 4 and Vascular Endotheliar Growth Factor in Children with Wilms Tumor
- VernacularTitle:基质细胞衍生因子-1、趋化因子受体4及血管内皮生长因子在小儿肾母细胞瘤中的表达
- Author:
zheng-hua, DONG
;
shu-feng, ZHANG
- Publication Type:Journal Article
- Keywords:
stromal cell-derived factor-1;
vascular endotheliar growth factor;
chemokine receptor 4;
Wilms tumor;
immunohistoche-mistry;
child
- From:Journal of Applied Clinical Pediatrics
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the role of vascular endotheliar growth factor(VEGF),chemokine receptor 4(CXCR4) and stromal cell-derived factor-1(SDF-1) in Wilms tumor as well as their relationship with clinical features by examining the expressions of VEGF,CXCR4 and SDF-1.MethodsThirty cases of Wilms tumor samples and 12 cases of adjacent kidney tissue were collected from the First and the Third Affiliated Hospital of Zhengzhou University from May 2003 to May 2008.Thirteen boys and 17 girls aging from 4 months to 7 years old of whom were 22 favorable histologic types and 8 unfavorable histologic types.By means of cytoplasm to dye buffy for masculine cell,staining intensity and percentage of positive tumor cells serve as the judgment criteria for being positive or negative.All tissues would be tested by hematoxylin and eosin stain at the same time.ResultsThe positive expression rate of VEGF,CXCR4 and SDF-1 in Wilms tumor were 63.33%,70.0% and 53.33%.Those in adjacent normal kidney tissue were 25.0%,8.3% and 16.7%.The 2 groups were statistically significant(Pa
