Correlative Factors of Bronchiolitis Inducing Asthma
- VernacularTitle:毛细支气管炎后支气管哮喘发生的相关因素
- Author:
hua, DENG
;
zhou, FU
- Publication Type:Journal Article
- Keywords:
bonchiolitis;
asthma;
correlative factor
- From:Journal of Applied Clinical Pediatrics
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlative factors of asthma after bronchiolitis.Methods Clinical data from 115 hospitalized patients with bronchiolitis were collected from Jan.2002 to May 2003,including age,gender,incidence season,family asthma history,birth weight,eczema,severity of bronchiolitis,pathogen,total and specific immunoglobulin E(IgE),overweight,smoking during pregnancy and feeding patterns;and the data of respiratory tract infection and wheezing onset in those cases were collected by clinic sevice and telephone follow-up in post-discharge for 5 years;the pollution status in living environment(coal dust and mine especially) and animal contact history(especially cats and dogs) were recorded.And the independent effect of risk factors was obtained,Logistic regression models were created for each outcome variable.Results Thirty-nine(33.9%) cases of 115 children with brochiolitis developed into asthma.There were significant differences between asthma and non-asthma group in family asthma history,recurrent lower respiratory tract infection(LRTI) under 1 year old,onset age,severity extent and obesity(P =0,0,0.004,0.004,0.020,respectively).The factors that contribute to the risk of asthma onset were incidence season,severe bronchiolitis,parental asthma,eczema and recurrent LRTI(OR=0.49,3.82,6.12,3.76 and 3.14,respectively P=0.000 7,0.026 0,0,0.030 9,0.000 5).But,the factors of gender,birth weight,congenital heartdisease,pollution status in living envi-ronment,animal contact history,feeding patterns,smoking during pregnancy,age when occured bronchioliyis,blood IgE and overweight had not correlated with asthma after bronchiolitis.Conclusions Severe bronchiolitis,parental asthma,eczema and recurrent LRTI under 1 year old correlate with development of asthma after bronchiolitis,however,falling ill in winter may be a protective factor in the progression of airway inflammation.
