Inhibition Effect of Methylprednisolone on Inflammatory Response during Immature Myocardial Ischemia Reperfusion Injury
- VernacularTitle:甲泼尼龙对幼鼠心肌缺血再灌注损伤免疫反应的抑制作用
- Author:
yan-fang, ZHANG
;
rui, YANG
;
jun-he, ZHANG
;
ting-tong, YANG
;
lei, LI
- Publication Type:Journal Article
- Keywords:
myocardial ischemia reperfusion injury;
inflammatory response;
interleukin;
methylprednisolone
- From:Journal of Applied Clinical Pediatrics
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of methylprednisolone on serum interleukin-1(IL-1),8,10 during immature myocardial ischemia reperfusion injury.Methods A total of 70 rats were randomly divided into 3 groups:control group(n=10),model group(n=30)and drug group(n=30).And the later 2 groups were observed at 0.5 h after ischemia and 2,4,8,12,24 h after reperfusion with 5 rats in each group and the control group were observed only at 12 h.The rat model of myocardial ischemia reperfusion injury(MIRI)was established.Morphology changes were observed and the levels of serum IL-1,8,10 were examined.Results Compared with model group,inflammatory response in drug group weaken clearly,IL-1,8 were lower(Pa
