Changes of Humoral Immunity in Newborn Infants with Hypoxic-Ischemic Encephalopathy and Its Correlative Factors
- VernacularTitle:缺氧缺血性脑病新生儿体液免疫功能的变化及其影响因素
- Author:
mei, YANG
;
li-xing, LIN
;
jie, WANG
;
zhi-ling, ZHANG
;
er-wei, YUAN
- Publication Type:Journal Article
- Keywords:
hypoxic-ischemic brain;
B-lymphocytes;
immunoglobulin;
complement;
infant,newborn
- From:Journal of Applied Clinical Pediatrics
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of humoral immunity in neonates with hypoxic-ischemic encephalopathy(HIE)and observe the influence of perinatal factors on humoral immune function.Methods Sixty-two neonates with HIE were enrolled and 30 healthy neonates were selected as control group.The percentages of CD19,CD25 of B lymphocyte were detected by Flow Cytometr.The levels of IgG,IgM,IgA and complement C3,C4 were detected by immune rate nephewlometry.The results were analyzed by SPSS 11.5 software.Results 1.The percentages of CD19+(17.93?3.10)%,CD19+CD25+(0.64?0.42)% and the levels of IgM(0.13?0.05)g/L,IgA(0.14?0.07)g/L and complement C3(0.62?0.12)g/L,C4(0.10?0.03)g/L in neonates with HIE were significantly lower than those in the healthy term neonates(Pa0.05).2.There were dignificant diffe-rences of the percentages of CD19+,CD19+CD25+ and the levels of IgM,IgA,complement C3,C4 among the different stages of HIE(Pa
