Influence of Nimodipine on [Ca~(2+)]i Levels in Red Blood Cell in Newborn Infants with Hypoxic-Ischemic Encephalopathy and Its Clinical Significance
- VernacularTitle:尼莫地平对缺氧缺血性脑病患儿红细胞胞质游离钙的影响及其临床意义
- Author:
min, JIN
;
xiao-ni, ZHANG
;
chao, CHEN
- Publication Type:Journal Article
- Keywords:
cerebral hypoxia-ischemia;
[Ca2+]i;
nimodipine;
infant,newborn
- From:Journal of Applied Clinical Pediatrics
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore change of RBC[Ca2+]i levels in neonates with hypoxic-ischemic encephalopathy(HIE)and the influence of nimodipine on RBC[Ca2+]i and its clinical significance.Methods Fifty-eight neonates with moderate and severe HIE were randomly divided into 2 groups including routine treatment group(n=28)and nimodipine group(n=30),and 20 healthy full-term neonates were selected as healthy control group.Based on the routine treatment,nimodipine[2 mg,0.5-1.0 ?g/(kg?min)] was given intravenously in the nimodipine group for 7-10 days.Blood samples were collected before and after treatment for 72 hours and 10-14 days,respectively.The levels of RBC[Ca2+]i were measured by Fura-2 pentakis(acetoxymethyl)ester[Fura-2/AM].The results were analyzed by SPSS 10.0 software.Results 1.The levels of RBC[Ca2+]i in neonates with HIE were significantly higher than those in healthy control group[(2.83?0.36)mmol/L vs(2.15?0.18)mmol/L,P
