Relationship between Plasma Brain Natriuretic Peptide,Endothelin-1 and Left Ventricular End Diastolic Vo-lume Index,Left Ventricular Ejection Fraction in Children with Heart Failure
- VernacularTitle:心力衰竭患儿血浆脑利钠肽、内皮素-1与左室舒张末期容量指数、左室射血分数的关系
- Author:
jian-mei, ZHAO
;
mei-yu, XU
- Publication Type:Journal Article
- Keywords:
heart failure;
brain natriuretic peptide;
endothelin-1;
left ventricular ejection fraction;
child
- From:Journal of Applied Clinical Pediatrics
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between plasma brain natriuretic peptide(BNP),endothelin-1(ET-1)and left ventricular end diastolic volume index(LVEDVI),left ventricular ejection fraction(LVEF)in children with heart failure and their clinical significance.Methods Forty-one children with heart disease were divided into Ⅰ,Ⅱ,Ⅲ and Ⅳ groups according to New York Heart Assciation(NYHA)heart functional class.Plasma BNP and ET-1 concentration were determined before and after treatment.All patients had echocardiographic study,including measurement of LVEDVI and LVEF.The relationship between plasma BNP,ET-1 and LVEDVI,LVEF were studied.Twenty healthy children were included in healthy control group,plasma BNP and ET-1 concentration were also determined.Results 1.Plasma BNP and ET-1 concentration in children with heart failure were significantly higher than those of healthy control group,and increased with the degree of heart failure.2.Plasma BNP and ET-1 concentration in children with heart failure were positively correlated with NYHA heart functional class(r=0.70,0.61 Pa
