Significance of Expression of Nuclear Factor-?B in Brain Tissues of Rats with Repeated Febrile Seizures
- VernacularTitle:核因子-?B在反复高热惊厥大鼠脑组织中表达的意义
- Author:
xiu-mei, YAN
;
guang-qian, LI
- Publication Type:Journal Article
- Keywords:
febrile seizure;
nuclear factor-?B;
hippocampus;
rat
- From:Journal of Applied Clinical Pediatrics
2006;0(24):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expressions of nuclear factor-?B(NF-?B)in brain tissue of rats with repeated febrile seizures(FS)and explore its significance in brain injury of rats with FS.Methods Fifty-one male SD rats were divided into 3 groups according to random number method:normal group(n=14),hyperthermic group(n=19),FS group(n=18).FS models were induced by placing rats in warm bath;the rats without FS after warm-bath were assigned as hyperthermic group ;the normal controls received no treatment.The expression of NF-?B was measured by immunohistochemistry.The apoptosis of brain tissue was determined by terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling(TUNEL).SPSS 13.0 software was applied for statistical treatment.Results In FS group,the number of the NF-?B positive neuron increased much more than that of hyperthermic group and normal group(Pa
