Detection Significance of Serum Insulin-Like Growth Factor-Ⅰ,Insulin-Like Growth Factor Binding Protein-3 in Children with Acute Lymphoblastic Leukemia
- VernacularTitle:急性淋巴细胞白血病患儿血清胰岛素样生长因子-Ⅰ及结合蛋白-3检测的意义
- Author:
wen-lin, ZHANG
;
dong-ju, ZHAO
;
yan-ling, GUI
;
tai-xin, SHI
- Publication Type:Journal Article
- Keywords:
insulin-like growth factor-Ⅰ;
insulin-like growth factor binding protein-3;
lymphoblastic leukemia,acute;
child
- From:Journal of Applied Clinical Pediatrics
2006;0(23):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the detection significance of insulin-like growth factor-I(IGF-I),IGF-binding protein-3(IGFBP-3) in children with acute lymphoblastic leukemia(ALL).MethodsSerum samples were obtained from 30 ALL children without any medication;serum control samples were obtained from 30 cases of healthy children.There were no significant differences of body weight,age and sex between 2 groups.All children had no case history of liver,kidney,malnutrition and endocrine system disease.IGF-Ⅰ was determined by radioimmunoassay kit.IGFBP-3 was determined by immunoradiometric kit.The data were analyzed with SPSS 11.0 software.ResultsThe level of IGF-Ⅰ in ALL group [(18.95?4.02)?106 g/L] was significantly lower than that in control group [(34.12?7.86)?106 g/L](t =9.412P
