Changes of Blood Coagulation and Fibrinolysis Function in Acute Leukemia Children Complicated with Disse-minated Intravascular Coagulation and Their Significances
- VernacularTitle:急性白血病并弥散性血管内凝血患儿凝血与纤溶功能变化的意义
- Author:
rui, YANG
;
zhi-quan, ZHANG
;
wen-ning, WEI
;
yan, YANG
;
san-jun, SONG
- Publication Type:Journal Article
- Keywords:
disseminated intravascular coagulation;
acute leukemia;
D-dimer;
antithrombin activity;
child
- From:Journal of Applied Clinical Pediatrics
2006;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of antithrombin activity(AT) and D-dimer in acute leukemia(AL)children complicated with disseminated intravascular coagulation(DIC) and to explore the changes of blood coagulation and fibrinolysis function.Methods Twenty-seven AL children without DIC were selected as AL group and 25 childern complicated with DIC were selected as observe group,36 health children were as control group.Plasma level of AT,D-dimer,fibrinogen,activated partial thromboplastin time and prothrombin time were tested by color substrate,immuno-latex turbidimetry,and coagulation method.And the rusults of AL group were compared with observe group and control group by SPSS 10.0 software.Results PT was significantly prolonged and the D-dimer in AL group and observation group were significantly higher than those in control group(Pa
