Curative Effect of Lovasatin Treating Hyperlipidemia in Children with Steroid Resistance Nephrotic Syndrome
- VernacularTitle:洛伐他汀对激素耐药性肾病综合征小儿高脂血症的疗效
- Author:
xue-mei, ZHANG
;
wen, WU
;
qing-xuan, LI
- Publication Type:Journal Article
- Keywords:
nephrotic syndrome;
hyperlipidemia;
lipid-lowing treatment;
lovasatin;
child
- From:Journal of Applied Clinical Pediatrics
2006;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect and security of lovasatin treating hyperlipidemia in children with steroid resistance nephrotic syndrome(SRNS).Methods Thirty-seven children with SRNS were administered lovasatin with normal liver function before lipid-lowing treatment.The changes of plasma lipids [total cholesterol(TC),trigly ceride(TG)] and lipoprotins [low density lipoprotein(LDL),very low density lipoprotein(VLDL),high density lipoprotein(HDL)],albumin(Alb),serum creatinine(Scr),aminotransferase(ALT),24 hours of urinary protein and drug side-effects were observated for 4 weeks.All children treated with regular glucocorticoids therapy for 2 months still presented with urinary protein significant positive.Results There were decreasing of plasma lipids and lipoproteins after 2 weeks of lovasatin treatment,especially for TG,24 hours of urinary protein(Pa
