Changes of Concentrations of Serum Interleukin-18 and Intercellular Adhesion Molecule-1 in Neonates with Hypoxic-Ischemic Encephalopathy
- VernacularTitle:缺氧缺血性脑病新生儿血清白细胞介素-18及细胞间黏附因子-1水平的变化
- Author:
jin-you, DENG
;
yong-zhen, WEN
;
kai-wen, LI
;
yu-ge, HUANG
- Publication Type:Journal Article
- Keywords:
interleukin-18;
intercellular adhesion molecule-1;
infant,newborn;
brain hypoxic;
brain ischemic
- From:Journal of Applied Clinical Pediatrics
2006;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe changes of serum concentrations of interleukin-18(IL-18) and intercellular adhesion molecule-1(ICAM-1) in neonates with hypoxic-ischemic encephalopathy(HIE) and to explore the correlation of the 2 indices and its effect on patients′condition.Methods Thirty newborn infants met the criteria for HIE.There were 16 cases in mild HIE group,14 cases in moderate and severe HIE group.Twenty normal newborn infants were used as control group.The serum concentrations of IL-18 and ICAM-1 of HIE group and control group were detected using ELISA on the third day and 7th day.Results 1.The IL-18 levels of the mild,moderate and severe HIE and control groups measured within 3 days of life were (120.1?12.7),(175.1?15.4),(100.3?12.5) ng/L,respectively.The concentrations of IL-18 in HIE groups were higher than that of control group(Pa
