Effect of Ligustrazine on Expression of Platelet-Derived Growth Factor-? Receptor and Extracellular Signal Regulated Kinase in Neonatal Rat Cardiac Myocytes in Vitro Induced by Angiotensin Ⅱ
- VernacularTitle:川芎嗪对血管紧张素Ⅱ诱导新生大鼠心肌细胞血小板源生长因子-?受体与细胞外信号调节激酶表达的影响
- Author:
yin-ping, SUN
;
da-wei, ZHANG
;
xing, WANG
- Publication Type:Journal Article
- Keywords:
ligustrazine;
angiotensin Ⅱ;
cardiac myocyte;
platelet-derived growth factor-? receptor;
extracellular signal regulated kinase
- From:Journal of Applied Clinical Pediatrics
2006;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of ligustrazine on the expression of platelet-derived growth factor-?(PDGF-?) receptor and extracellular signal regulated kinase(ERK1/2) induced by angiotensin Ⅱ(AngⅡ) in cardiac myocytes,and explore the mechanism of therapeutic.Methods Cultured cardiac myocytes of neonatal rats were treated with 10-7 mol/L AngⅡ as Ang Ⅱ group,10-7 mol/L AngⅡ plus 10 mg/L ligustrazine as ligustrazine group,the normally cultured neonatal rat cardiac myocytes as control group.Protein synthesis was measured by -leucine incorporation,and the expression of PDGF-? receptor and ERK1/2 was detected by Western blot.SPSS 11.0 software was used to analyze the data.Results There were significant differences among 3 groups(F=20.71 P
