Research on the Correlation between Maternal Negative Major Life Events and Congenital Heart Disease during Early Pregnancy
- VernacularTitle:孕早期重大负性生活事件与子代先天性心脏病病因的关联
- Author:
feng, LIU
;
fang-biao, TAO
- Publication Type:Journal Article
- Keywords:
heart defects,congenital;
case-control study;
life events
- From:Journal of Applied Clinical Pediatrics
2006;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the relationship between maternal negative major life events during the first trimester and incidence of congenital heart diseases(CHD) in their offspring.Methods The 4-2-1 medical information was referred and screen CHD children who were confirmed by Municipal hospitals over.A 1:2 case-control study was carried out with face-to-face structured interviews and telephone interviews to investigate parents of 116 children with CHD and 232 healthy matched children,including the parents′ demographic variables(such as whether the working environment exposure to toxic and hazardous substances 1 year before pregnancy,et al),mother′s experience of previous adverse pregnancy,duration of pregnancy condition(such as maternal negative major life events during the first trimester,the history of catching a cold or fever during the first trimester.The possible risk factors were analyzed by simple factors Logistic regression methods.Then,diagnosing the colinearity among these suspicious risk factors,and rejecting it if necessary.Finally,multiple factors conditional Logistic stepwise regression was used to filter once more.Results The results revealed that maternal negative major life events and taking medicine during the first trimester,mother′s experience of previous adverse pregnancy were related to the occurrence of CHD in the offspring.Moreover,maternal negative major life events during the first trimester play the most important role(OR=1.810).Conclusions Strengthening mothers′ mental health and controlling or reducing maternal negative major life events during the first trimester may be effective in reducing the risk of CHD.
