Change of the Level of Serum Leptin in Children with Primary Nephritic Syndrome Treated with Glucocorticosteroid
- VernacularTitle:原发性肾病综合征患儿激素治疗前后血清瘦素水平变化
- Author:
ling, LIU
;
dong-feng, ZHANG
;
li, WANG
;
qian, FANG
;
gui-xia, LI
- Publication Type:Journal Article
- Keywords:
nephrotic syndrome,primary;
glucocorticosteroid;
leptin;
child
- From:Journal of Applied Clinical Pediatrics
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the change of the level of serum leptin in children with primary nephritic syndrome(PNS)treated with glucocorticosteroid.Methods Totally 30 PNS patients and 26 healthy children in whom were a matchable age,sex and body mass index(BMI)with the PNS patients were recruited in this study.The PNS patients were treated with prednisone in middle-term or long-term coure of treatment.Serum leptin and BMI of PNS patients were abserved before treatment,after 2,6 months treatment and in the end.The se-rum total cholesteroc(TC)and triglyeride(TG)were abserved in PNS patients after 2,6 months treatment and in the end.Results The se-rum leptin level was(2.75?2.29)?g/L in the PNS patient before treatment and control group was(2.65?2.22)?g/L.There was not significantly different between the PNS patient and control group.The level of serum leptin after 2 months treatment was(9.29?7.19)?g/L and BMI was(18.12?1.90)kg/m2.They were higher than that in control group,6 months treatment and in the end(Pa
