Study of Variation and Correlation of Plasma Tumor Necrosis Factor-? and Transforming Growth Factor-?1 in Children with Henoch-Schonlein Purpura Nephritis
- VernacularTitle:紫癜性肾炎患儿血浆肿瘤坏死因子-?、转化生长因子-?1水平变化及相关性研究
- Author:
xiao-qing, YU
;
jin, GAO
;
liang, FU
;
duo, ZHANG
- Publication Type:Journal Article
- Keywords:
nephritis,purpura;
tumor necrosis factor-?;
transforming growth factor-?1
- From:Journal of Applied Clinical Pediatrics
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the variation and correlation between tumor necrosis factor-?(TNF-?)and transforming growth factor-?1(TGF-?1)in children with Henoch-Schonlein purpura nephritis(HSPN)in plasma and explore their effects on kidney lesion in children with Henoch-Schonlein purpura(HSP).Methods Plasma TNF-? and TGF-?1 were determined with enzyme-linked immunosorbent assay(ELISA)in 30 cases with HSP,38 cases with HSPN and 30 normal controls,urinary protein excretion with urinary analyze method in these children.Renal biopsies were performed and renal biopsy specimens were observed by light,immunofluorescence and electron microscopy in 32 out of 38 cases with HSPN.The SPSS 11.0 software was used to analyze the data.Results 1.Comparing with normal controls,the plasma level of TNF-? and TGF-?1 in children with HSP increased with significant difference in statistics(Pa
