Endoplasmic Reticulum Stress Activated by Recurrent Febrile Seizures in Developing Rats
- VernacularTitle:发育期大鼠反复热性惊厥激活内质网应激
- Author:
xiao-yan, LIU
;
jiong, QIN
;
zhi-xian, YANG
;
ying, HAN
;
jing, CHEN
- Publication Type:Journal Article
- Keywords:
febrile seizures;
glucose-regulated protein 78;
endoplasmic reticulum stress
- From:Journal of Applied Clinical Pediatrics
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the recurrent febrile seizures(FS)influence on adrenocorticotropic hormone(ATCH)and glucose-regulated proein 78(Grp78)and explore the association between recurrent FS and endoplasmic reticulum stress in the brain of developing rats.Methods Forty specefic pathogen free(SPF)Sprague-Dawley rats aged 21 days were randomly divided into control group(immersed in 37.0 ℃ water,n=12)and hyperthermia treated group(immersed in 44.8 ℃ water,n=28),which was subdivided into hyperthermia group(n=12)and recurrent FS group(n=16)according to whether seizures occurred or not.Seizures were induced 10 times in a bath of warm water,once every 2 days.The plasma content of ACTH was detected by radioimmunoassay.The protein level of Grp78 was examined by immunohistochemistry staining and Western blot.Results After recurrent FS,the plasma content of ACTH increased significantly in FS group compared with control group(Pa
