Study on Human Leukocyte Antigen-B and-DR Alleles Polymorphism in Children with Asthma in Zhuang and Han Nationality in Guangxi
- VernacularTitle:广西壮、汉族哮喘儿童人类白细胞抗原-B、-DR基因的多态性
- Author:
qing-ling, XIE
;
ling, QIN
;
wei, JIAO
;
hong, ZHEN
;
lin, WANG
;
xiao-chun, LIU
;
qiong-yan, HU
;
ying, TAN
;
hong-fei, PAN
;
wen-shan, HUANG
;
yuan-feng, LU
;
hua, DU
- Publication Type:Journal Article
- Keywords:
Zhuang nationality;
Han nationality;
asthma;
human leucocyte antigen;
Guangxi
- From:Journal of Applied Clinical Pediatrics
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between the characteristics of the genetic polymorphism of human leukocyte antigen (HLA)-B and HLA-DR alleles and asthma in Guangxi Zhuang and Han nationality children.Methods Eighty-four blood-unrelated asthmatic individuals,57 cases of Han nationality and 27 cases of Zhuang children with asthma,and 168 healthy controls,included 83 cases of Han nationality and 85 cases of Zhuang people without asthma and atopy living in Nanning region of Guangxi were involved in the study.All asthmatic patients′serum total IgE levels were measured with UniCAP Pharmacia system,and skin-prick test with ten kinds of inhalant allergens were taken and pulmonary functions were measured among the patients.HLA oligonucleotide array was used to 40 gene alleles of HLA-B and 26 HLA-DR.Comparison of the frequency distribution of HLA-DR alleles and HLA-B alleles in 2 groups was evaluated by chi-square test,and the risk for asthma of the HLA allele′s carriers was valuated by OR value.Results Twenty-seven alleles at HLA-B locus and 21 alleles at HLA-DR were detected.The distribution of HLA-B46,HLA-DRB1070X and HLA-DRB111XX alleles only in Han people was distinctive in the asthmatic patients compared with those in healthy controls(Pa
