Effect of Intrauterin Hypoxia on Proliferation of Neural Stem Cells and Memory and Learning Capacity of Juvenile Rats
- VernacularTitle:宫内缺氧对幼年大鼠神经干细胞增殖及学习记忆能力的影响
- Author:
xiao-ming, ZHONG
;
xu-dong, CHEN
;
mei, ZHONG
;
hong, YU
;
jing, MA
- Publication Type:Journal Article
- Keywords:
hypoxia;
hippocampus;
neural stem cells;
proliferation;
learning
- From:Journal of Applied Clinical Pediatrics
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of intrauterin hypoxia on proliferation of neural stem cells(NSCs)and memory and learning capacity of juvenile rats.Methods Conceiving female SD rats(n=20)were divided randomly into 2 groups:control group(n=10)and hypoxia group(n=10).The rats of hypoxia group were put into 3 gases incubator to make the injured brain newborn rats model,rats of control group were not done so.The juvenile rats were taken to do the experiment of water maze after they were born in 30 d,then killed when the experiment was over,the brains of the rats were taken,immobilization,paraffin imbedding,slicing(hippocampus),common immunohistochemistry staining were used to detect the Nestin positive NSCs.Results Optical density of Nestin positive cells in hippocampus dentation of hypoxia group(0.16?0.10)was higher than that of control group(0.15?0.09)(t=3.24 P
