Relationship between the Ratio of Plasma Adrenomedullin/Endothelin-1 and Neuron-Specific Enolase in Full-Term Neonates with Hypoxic-Ischemic Encephalopathy
- VernacularTitle:缺氧缺血性脑病新生儿血浆肾上腺髓质素/内皮素-1值与血清神经元特异性烯醇化酶的相关性
- Author:
shi-fa, ZHANG
;
ming-xiong, ZHOU
;
shuang-gen, MAO
;
chang-sheng, DOU
;
guo-cheng, XU
- Publication Type:Journal Article
- Keywords:
hypoxic-ischemic encephalopathy;
adrenomedullin;
endothelin-1;
ratio;
neuron-specific enolase
- From:Journal of Applied Clinical Pediatrics
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship of the ratio of plasma adrenomedullin(AM)and endothelin-1(ET-1)with serum concentration of neuron-specific enolase(NSE)in full-term neonates with hypoxic-ischemic encephalopathy(HIE).Methods Plasma concentrations of AM,ET-1 and serum NSE from 32 full-term neonates with HIE were detected by radioimmunoassay(RIA)on the 1,3 and 7 d after parturition,30 neonates in the corresponding periods in our hospital were employed as controls.The infants with HIE were divided into mild,moderate or severe group in terms of diagnostic standard of HIE.Results 1.Plasma concentrations of AM and ET-1 in newborns with mild,moderate or severe HIE were significantly higher than that of control group at 1 d after life with a decline from 3-7 d(Pa
