Alteration of Apoptosis and Astrocyte in Neonatal Hypoxic-Ischemic Encephalopathy
- VernacularTitle:缺氧缺血性脑病新生儿神经细胞凋亡及星形胶质细胞的变化
- Author:
hui, WU
;
gui-bin, ZHU
;
dong-xuan, WANG
- Publication Type:Journal Article
- Keywords:
infant,newborn;
hypoxic-ischemia,brain;
apoptosis;
astrocyte
- From:Journal of Applied Clinical Pediatrics
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the alteration of astrocyte and apoptosis in neonatal hypoxic-ischemic encephalopathy(HIE).Me-thods The pathological brain specimens of 25 newborns who died of HIE were observed macroscopically and microscopically,included male 14 cases and female 11 cases.The immunochemistry staining with glial fibrillary acidic protein(GFAP)and in situ end terminal dexynucleotidy 1 transferase mediated deoxyuridine triphosphate-biotion nick and labeling(TUNEL)methods were used to observe the changes of astrocyte and the neurons apoptosis in HIE.The relationship between the change of astrocyte and the neurons apoptosis and the occurrence of HIE and course of disease were further synthetically analyzed.Results The brain specimens of 25 newborn HIE had apoptosis cells at the different level.The degree of apoptosis of cerebral neurons was severe in the cases of 24 h-6 d survival(P
