Changes of Aspartate and Glutamate in Hippocampus Formation and Cerebrospinal Fluid in Kainite Acid Induced Epilepsy Rat
- VernacularTitle:海人酸致大鼠海马及脑脊液谷氨酸及天冬氨酸变化的意义
- Author:
chun-feng, WU
;
song-ming, HUANG
;
guo, ZHENG
;
xiao-peng, LU
- Publication Type:Journal Article
- Keywords:
epilepsy;
hippocampus formation;
glutamate;
aspartate;
cerebrospinal fluid
- From:Journal of Applied Clinical Pediatrics
2006;0(24):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of contents of glutamate (Glu) and aspartate (Asp) in hippocampus formation and cerebrospinal fluid (CSF) in kainite acid(KA) induced epilepsy rats.Methods SD rats(n=40) were divided into 2 groups randomly:the KA group [intracerebroventricular injection(icv) of KA, 2 ?g/kg] and control group(icv of NS). KA group were divided into 4 groups at 6 h,1,3 and 7 d,each group 8 rats.High pressure liquid chromatgraphy(HPLC) was used to assess the concentrations of Glu and Asp in hippocampus formation and CSF.Results In the hippocampus, the contents of Glu and Asp increased continuously 1 d after seizure , but not different from those of control group.Three days later, only Glu became significantly different from control group. However, the contents of Glu and Asp in the CSF were significantly different from the control 6 h after seizure.Conclusion The contents of excite amino acid (especially Glu)in CSF increase immediately after KA injection, which are earlier than those in hippocampus formation.
