Protective Effect of Topiramate and Folic Acid on Mitochondrial Damage in Hippocampal Neurons during Pentylenetetrazol-Induced Kindling in Immature Rats
- VernacularTitle:托吡酯联合叶酸对戊四氮致癫幼鼠海马神经元线粒体损伤的保护作用
- Author:
ping, WANG
;
rong-na, REN
;
shu-ying, CAI
;
xin-min, CHEN
;
li-yan, YE
- Publication Type:Journal Article
- Keywords:
topiramate;
folic acid;
epilepsy;
mitochondria;
ultrastructure
- From:Journal of Applied Clinical Pediatrics
2006;0(24):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore protective effect of topiramate (TPM) and folic acid (FA) on mitochondrial damage in hippocampal CA3 neurons during pentylenetetrazol- induced kindling in immature rats.Methods Pentylenetetrazol (PTZ) - induced kindling in rats was used to establish rat models of epilepsy.Forty-eight 3-week-old male Wistar rats were randomly divided into 4 groups: two therapy groups with TPM 40 mg/(kg?d) or TPM 40 mg/(kg?d) and FA 5 mg/(kg?d) administration, 2 control groups (positive control group and negative control group) with the equal amount of distilled water administration. The seizure behaviors of rats were evaluated. Two months later, the rats were killed and the brain sections were made. The mitochondrial ultrastructures of neurons in hippocampal CA3 region were observed with transmission electron microscope.Results In the positive control group, the frequency of seizure was (48.4 ? 3.7)times, while in TPM group (44.3 ? 3.1)times and in TPM and FA group(40.8 ? 3 .7)times.The differences were significant among three groups (Pa
