Effect of Status Epilepticus on Learning and Memory and Expression of Hippocampal Phosphorylated c-AMP Response Element Binding Protein in Developmental Rats
- VernacularTitle:癫癎持续状态对发育期大鼠学习记忆及海马磷酸化的c-AMP反应元件结合蛋白表达的影响
- Author:
xiu-li, WANG
;
hong-li, TANG
;
guo-ling, SUO
- Publication Type:Journal Article
- Keywords:
status epilepticus;
learning and memory;
c-AMP response element binding protein;
Morris water maze;
Y maze
- From:Journal of Applied Clinical Pediatrics
2006;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of status epilepticus(SE) on learning and memory and expression of phosphorylated c-AMP response element binding protein(pCREB) in hippocampus in developmental rats.Methods Developmental male SD rats were assigned randomly to two groups:the SE rats,induced by intraperitoneal injection of pentylenetetrazole(PTZ);normal saline(NS) control group,received saline intraperitoneal.Learning and memory test with the Morris water maze and Y maze were performed at 7 days after SE.After testing,a subset of rats were killed and the brain was evaluated for pCREB immunostaining,an important transcription factor underlying learning and memory.Results In SE group,the mean escape latency of searching the platform significantly prolonged(P
