Modulation of Lentinan on Airway Inflammation and Helper T Lymphocyte Cell 1/Helper T Lymphocyte Cell 2 Imbalance in Rats′ Model of Asthma
- VernacularTitle:香菇多糖对哮喘大鼠模型气管炎性反应及辅助性T淋巴细胞1/辅助性T淋巴细胞2免疫应答失衡的调节
- Author:
lei, WANG
;
gao-zhong, CAO
;
le-ping, YE
;
li, FANG
- Publication Type:Journal Article
- Keywords:
asthma;
interleukin-4;
interferon-?;
tracheitis;
helper T lymphocyte cells imbalance;
lentinan
- From:Journal of Applied Clinical Pediatrics
2006;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study helper T lymphocyte cell(Th)1/Th2 imbalance in rats′ model of asthma and the modulation of lentinan(LNT) on the airway inflammation and Th1/Th2 imbalance.Methods Thirty male SD rats were randomly divided into control,asthma and LNT groups.In the experiment,the rat model of asthma was established by the ovalbumin(OVA) challenge methods.Eosinophils(Eos) number and differentiated cell number in bronchoalveolar lavage fluid(BALF) were counted by different count fluids.The levels of IL-4 and IFN-? in BALF were measured by sandwich enzyme linked immunosorbent assay(ELISA).Results 1.The Eos count in BALF and the ratio of eosinophils to the total cell number(Eos%) of asthma group were significantly higher than those of the control group(t=21.94,12.81 Pa
