Change of Helper T Lymphocyte Cell 1/Helper T Lymphocyte Cell 2 Cytokine in Food Allergy Animal Model
- VernacularTitle:食物过敏动物模型中辅助性T淋巴细胞1/辅助性T淋巴细胞2相关细胞因子变化
- Author:
qun, WU
;
jie, SHAO
;
shan-chang, YU
;
yun-zhu, LI
- Publication Type:Journal Article
- Keywords:
food allergy;
helper T lymphocyte cells;
cytokine
- From:Journal of Applied Clinical Pediatrics
2006;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the function of helper T lymphocyte cell(Th)1/Th2 cytokine in food allergy development.Methods A total 110 Balb/c mice were randomly divided into 2 groups:control group(40 mice)and food allergy group(70 mice).Food allergy animal models were established by ovalbumin,performed by skin prick test;in positive reaction mice,serum specific IgE,IL-4 and IFN-? were measured by enzyme linked immuosorbent assay(ELISA),and intestinal pathology were performed,and the mRNA expressions of IL-10,TGF-? in intestinal were measured by real-time PCR assay.Results In food allergy group,the mRNA expression of IL-10,TGF? in intestinal decreased(P
